glimepiride

Ligand id: 6820

Name: glimepiride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 133.06
Molecular weight 490.22
XLogP 4.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1995))
IUPAC Name
3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide
International Nonproprietary Names
INN number INN
5718 glimepiride
Synonyms
Amaryl® | glimepride | HOE-490 | Sugral®
Database Links
CAS Registry No. 93479-97-1
ChEMBL Ligand CHEMBL1481
DrugBank Ligand DB00222
GtoPdb PubChem SID 178103426
PubChem CID 3476
Search Google for chemical match using the InChIKey WIGIZIANZCJQQY-RUCARUNLSA-N
Search Google for chemicals with the same backbone WIGIZIANZCJQQY
Search PubMed clinical trials glimepiride
Search PubMed titles glimepiride
Search PubMed titles/abstracts glimepiride
Search UniChem for chemical match using the InChIKey WIGIZIANZCJQQY-RUCARUNLSA-N
Search UniChem for chemicals with the same backbone WIGIZIANZCJQQY
Wikipedia Glimepiride
Comments
Only approved by the EMA (2007) to be used in combination with pioglitazone (Tandemact®). Note that the PubChem CID listed above refers to the non-isomeric molecule. We show the isomeric form which corresponds to the structure held with the INN record for this compound.