tolbutamide

Ligand id: 6848

Name: tolbutamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 83.65
Molecular weight 270.1
XLogP 2.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1979))
IUPAC Name
3-butyl-1-(4-methylbenzenesulfonyl)urea
International Nonproprietary Names
INN number INN
602 tolbutamide
Synonyms
Orinase® | tolbutamide sodium
Database Links
CAS Registry No. 64-77-7
ChEMBL Ligand CHEMBL782
DrugBank Ligand DB01124
PubChem CID 5505
Search Google for chemical match using the InChIKey JLRGJRBPOGGCBT-UHFFFAOYSA-N
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Wikipedia Tolbutamide
Comments
A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 ( KCNJ11).