denosumab

Ligand id: 6886

Name: denosumab

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Classification
Compound class Antibody
Approved drug? Yes (FDA and EMA (2010))
International Nonproprietary Names
INN number INN
8653 denosumab
Synonyms
AMG-162 | M05BX04 | Prolia® | Xgeva®
Database Links
Specialist databases
IMGT/mAb-DB 249
Other databases
GtoPdb PubChem SID 178103468
PubChem SID 178103468
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Wikipedia Denosumab
Comments
Denosumab suppresses the activity of RANK ligand (RANKL), which normally promotes bone removal and resorption, but which becomes over active in many bone loss diseases.
Denosumab is produced from CHO cells stably expressing recombinant antibody component proteins [1].