tazarotene

Ligand id: 6952

Name: tazarotene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 64.49
Molecular weight 351.13
XLogP 6.22
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1997))
IUPAC Name
ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
International Nonproprietary Names
INN number INN
7328 tazarotene
Synonyms
AGN-190168 | Tazorac® | Zorac®
Database Links
CAS Registry No. 118292-40-3
ChEMBL Ligand CHEMBL1657
DrugBank Ligand DB00799
PubChem CID 5381
Search Google for chemical match using the InChIKey OGQICQVSFDPSEI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone OGQICQVSFDPSEI
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Search UniChem for chemical match using the InChIKey OGQICQVSFDPSEI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone OGQICQVSFDPSEI
Wikipedia Tazarotene
Comments
Tazarotene is a vitamin A-like retinoid that binds all isoforms of the retinoic acid receptor, but may show selectivity for the β, and γ isoforms acting via which may result in altered gene expression that provides the beneficial effects on skin condition. Tazarotene is essentailly a prodrug, with tazarotenic acid (PubChem CID 147525) being the active metabolite.