romidepsin

Ligand id: 7006

Name: romidepsin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 193.3
Molecular weight 540.21
XLogP 3.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2009))
IUPAC Name
(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
International Nonproprietary Names
INN number INN
8656 romidepsin
Synonyms
FK228 | FR901228 | Istodax®
Database Links
CAS Registry No. 128517-07-7
ChEMBL Ligand CHEMBL343448
PubChem CID 5352062
Search Google for chemical match using the InChIKey OHRURASPPZQGQM-GCCNXGTGSA-N
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Search UniChem for chemical match using the InChIKey OHRURASPPZQGQM-GCCNXGTGSA-N
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Wikipedia Romidepsin
Comments
Romidepsin is an anticancer agent originally isolated from the bacterium Chromobacterium violaceum, but subsequently produced synthetically. Romidepsin is an inhibitor of Class II histone deacetylases (HDACs).