perampanel

Ligand id: 7050

Name: perampanel

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 56.99
Molecular weight 349.12
XLogP 6.46
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA and EMA (2012))
IUPAC Name
2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile
International Nonproprietary Names
INN number INN
8834 perampanel
Synonyms
E2007 | ER-155055-90 | Fycompa®
Database Links
CAS Registry No. 380917-97-5
ChEMBL Ligand CHEMBL1214124
DrugBank Ligand DB08883
PubChem CID 9924495
RCSB PDB Ligand 6ZP
Search Google for chemical match using the InChIKey PRMWGUBFXWROHD-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PRMWGUBFXWROHD
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Search UniChem for chemical match using the InChIKey PRMWGUBFXWROHD-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone PRMWGUBFXWROHD
Wikipedia Perampanel
Comments
Perampanel is an anticonvulsant. The drug is administered as perampanel hydrate.
It is first and only FDA-approved non-competitive AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist.