topotecan

Ligand id: 7101

Name: topotecan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 103.2
Molecular weight 421.16
XLogP 0.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Approved drug? Yes (EMA and FDA (1996))
International Nonproprietary Names
INN number INN
6783 topotecan
Synonyms
Hycamtin® | SK-S-104864-A
Database Links
CAS Registry No. 123948-87-8
ChEBI CHEBI:63632
ChEMBL Ligand CHEMBL84
DrugBank Ligand DB01030
PubChem CID 60700
RCSB PDB Ligand TTC
Search Google for chemical match using the InChIKey UCFGDBYHRUNTLO-QHCPKHFHSA-N
Search Google for chemicals with the same backbone UCFGDBYHRUNTLO
Search PubMed clinical trials topotecan
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Search UniChem for chemical match using the InChIKey UCFGDBYHRUNTLO-QHCPKHFHSA-N
Search UniChem for chemicals with the same backbone UCFGDBYHRUNTLO
Wikipedia topotecan
Comments
Topotecan is an analogue of camptothecin, an anticancer drug which causes DNA strand breaks.
Marketed formulations may contain topotecan hydrochloride (PubChem CID 60699).