amlexanox

Ligand id: 7113

Name: amlexanox

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 102.51
Molecular weight 298.1
XLogP 3.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
Withdrawn drug? Yes
IUPAC Name
2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
International Nonproprietary Names
INN number INN
5950 amlexanox
Synonyms
AA-673 | Amlexanox® | Aphthasol® | CHX-3673
Database Links
CAS Registry No. 68302-57-8
ChEMBL Ligand CHEMBL1096
DrugBank Ligand DB01025
PubChem CID 2161
RCSB PDB Ligand ANW
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Wikipedia Amlexanox
Comments
Amlexanox has anti-inflammatory [1], antiallergic and immunomodulatory actions [2]. Proposed to inhibit IKKδ and TBK1, albeit with low potency [5].