nizatidine

Ligand id: 7248

Name: nizatidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 139.55
Molecular weight 331.11
XLogP 2.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1988))
IUPAC Name
dimethyl[(4-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}-1,3-thiazol-2-yl)methyl]amine
International Nonproprietary Names
INN number INN
5194 nizatidine
Synonyms
Axid® | LY-139037
Database Links
CAS Registry No. 76963-41-2
ChEMBL Ligand CHEMBL653
DrugBank Ligand DB00585
PubChem CID 3033637
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Wikipedia Nizatidine
Comments
Nizatidine is a histamine H2 receptor antagonist. It is structurally related to ranitidine but has a thiazole ring substitution in place of the furan ring in ranitidine. Nizatidine was the last new histamine H2 receptor antagonist to be approved prior to proton pump inhibitors reaching the clinic.