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Synonyms: AMG-145 | AMG145 | Repatha®
evolocumab is an approved drug (EMA & FDA (2015))
Compound class:
Antibody
Comment: Evolocumab is a clinically approved anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) monoclonal antibody. Peptide sequences for this antibody are available from its IMGT/mAb-DB link. The development and discovery of this antibody is described in patent US8030457, where SEQ IDs 23 and 49 comprising clone 21B12 light and heavy chain variable regions respectively, match the peptide sequences in the INN record for evolocumab.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
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| Compound class | Antibody |
| Approved drug? | Yes (EMA & FDA (2015)) |
| International Nonproprietary Names |
|
| INN number | INN |
| 9643 | evolocumab |
| Synonyms |
| AMG-145 | AMG145 | Repatha® |
| Database Links |
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| Specialist databases | |
| IMGT/mAb-DB | 448 (Hs) |
| Other databases | |
| CAS Registry No. | 1256937-27-5 (source: Scifinder) |
| GtoPdb PubChem SID | 178103915 |
| PubChem SID | 178103915 |
| Search PubMed clinical trials | evolocumab |
| Search PubMed titles | evolocumab |
| Search PubMed titles/abstracts | evolocumab |
| Wikipedia | Evolocumab |
