albiglutide

Ligand id: 7386

Name: albiglutide

Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA and EMA (2014))
International Nonproprietary Names
INN number INN
8829 albiglutide
Synonyms
Eperzan® | GSK716155 | Tanzeum®
Database Links
Specialist databases
IMGT/mAb-DB 397
Other databases
ChEMBL Ligand CHEMBL2107841
GtoPdb PubChem SID 178103958
Search PubMed clinical trials albiglutide
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Search PubMed titles/abstracts albiglutide
Wikipedia Albiglutide
Comments
Albiglutide is recombinant protein engineered by fusing the gene for glucagon-like peptide 1 (GLP-1; an incretin secreted in the gut) with the gene for human albumin. In this case the GLP-1 appears to contain an amino acid substitution (Ala to Glu at the C-terminal) directly adjacent to the dipeptidyl peptidase-4 (DPP-4; the enzyme responsible for in vivo degradation of GLP-1) hydrolysis site, which renders the peptide resistant to cleavage by this enzyme [3,5]. In conjunction with the fusion to albumin [2] this drug has an extended half-life compared to other approved drug GLP-1 mimetics.