pirfenidone

Ligand id: 7532

Name: pirfenidone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 20.31
Molecular weight 185.08
XLogP 3.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (EMA (2011), FDA (2014))
IUPAC Name
5-methyl-1-phenylpyridin-2-one
International Nonproprietary Names
INN number INN
3825 pirfenidone
Synonyms
AMR-69 | Esbriet®
Database Links
CAS Registry No. 53179-13-8
ChEMBL Ligand CHEMBL1256391
DrugBank Ligand DB04951
PubChem CID 40632
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Wikipedia Pirfenidone
Comments
Pirfenidone is an anti-fibrotic drug. In addition to its proven anti-fibrotic effects in lung tissue, pirfenidone-induced in vitro and in vivo anti-fibrotic activity has been reported in experimental liver and renal fibrosis [2,4].