dextropropoxyphene

Ligand id: 7593

Name: dextropropoxyphene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 29.54
Molecular weight 339.22
XLogP 7.63
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
[(2S,3R)-4-dimethylamino-3-methyl-1,2-di(phenyl)butan-2-yl] propanoate
International Nonproprietary Names
INN number INN
740 dextropropoxyphene
Synonyms
(+)-alpha-propoxyphene | Darvon® | propoxyphene
Database Links
CAS Registry No. 469-62-5
ChEMBL Ligand CHEMBL1213351
DrugBank Ligand DB00647
PubChem CID 10100
Search Google for chemical match using the InChIKey XLMALTXPSGQGBX-GCJKJVERSA-N
Search Google for chemicals with the same backbone XLMALTXPSGQGBX
Search PubMed clinical trials dextropropoxyphene
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Search UniChem for chemical match using the InChIKey XLMALTXPSGQGBX-GCJKJVERSA-N
Search UniChem for chemicals with the same backbone XLMALTXPSGQGBX
Wikipedia Dextropropoxyphene
Comments
Dextropropoxyphene is principally an opioid analgesic. Chemically it is an optical isomer of levopropoxyphene (the (2R,3S) optical isomer with PubChem CID 200742); dextropropoxyphene being the (2S,3R) enantiomer. Marketing in Europe and the US has been discontinued due to concerns of fatal overdoses and heart arrhythmias.