conestat alfa

Ligand id: 7627

Name: conestat alfa

Classification
Compound class Peptide or derivative
Approved drug? Yes (EMA (2010), FDA (2014))
International Nonproprietary Names
INN number INN
8899 conestat alfa
Synonyms
rhC1INH | Ruconest®
Database Links
GtoPdb PubChem SID 223365962
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Comments
Conestat alfa is a recombinant analogue of the human C1 esterase inhibitor produced by recombinant DNA technology (in transgenic rabbits). The protein sequence of the enzyme peptide chain is identical to the endogenous human enzyme encoded by the SERPING1 gene (P05155) [1], but it lacks the 22 amino acid signal peptide.
Three nanofiltered/virus filtered, pasteurized, human plasma–derived C1 esterase inhibitor concentrates are already approved by international approval agencies; Berinert® (eMC link), Cetor® (available in the Netherlands and Turkey) and Cinryze® (EMA link).