AZD8529

Ligand id: 7678

Name: AZD8529

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.73
Molecular weight 487.18
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one
Synonyms
AZD 8529 | AZD-8529
Database Links
GtoPdb PubChem SID 223366013
PubChem CID 25125217
Search Google for chemical match using the InChIKey IPCYZQQFECEHLI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IPCYZQQFECEHLI
Search UniChem for chemical match using the InChIKey IPCYZQQFECEHLI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone IPCYZQQFECEHLI
Comments
AZD8529 is a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator. Since the original schizophrenia indication is not being pursued it is offered for clinical and preclinical research to explore novel biology with a view to repurposing (it was also in the 2012 NCATS set). Discussed as Case Study (1) in the AZ 2014 review paper [3].