AZD6703

Ligand id: 7687

Name: AZD6703

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 55.89
Molecular weight 417.22
XLogP 2.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]benzamide
Synonyms
AZ 12012199 | AZ-12012199 | AZ12012199 | AZD 6703 | AZD-6703
Database Links
CAS Registry No. 1083381-65-0 (source: SciFinder)
ChEMBL Ligand CHEMBL2031465
GtoPdb PubChem SID 223366022
PubChem CID 11373432
RCSB PDB Ligand NQB
Search Google for chemical match using the InChIKey ZMAZXHICVRYLQN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZMAZXHICVRYLQN
Search UniChem for chemical match using the InChIKey ZMAZXHICVRYLQN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZMAZXHICVRYLQN
SynPHARM 80146 (in complex with mitogen-activated protein kinase 14)
Comments
AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).
This compound was in the AstraZeneca/MRC repurposing list from 2011.