AZD1775

Ligand id: 7702

Name: AZD1775

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 100.96
Molecular weight 500.26
XLogP 2.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
Synonyms
AZD 1775 | AZD-1775 | MK-1775 | MK1775
Database Links
CAS Registry No. 955365-80-7
ChEMBL Ligand CHEMBL1976040
PubChem CID 24856436
Search Google for chemical match using the InChIKey BKWJAKQVGHWELA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BKWJAKQVGHWELA
Search UniChem for chemical match using the InChIKey BKWJAKQVGHWELA-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BKWJAKQVGHWELA
Comments
AZD1775 inhibits WEE1 G2 checkpoint kinase. It was developed as a potential adjunctive therapeutic for advanced solid tumours. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.