AZD2927

Ligand id: 7704

Name: AZD2927

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 43.78
Molecular weight 308.19
XLogP 2.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-fluoro-N-[(2S)-1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl]-N,3-dimethylbenzamide
Synonyms
AZD 2927 | AZD-2927
Database Links
GtoPdb PubChem SID 223366037
PubChem CID 57345449
Search Google for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N
Search Google for chemicals with the same backbone GAHPWXLXWUVMIV
Search UniChem for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N
Search UniChem for chemicals with the same backbone GAHPWXLXWUVMIV
Comments
AZD2927 blocks the potassium channels Kir3.1/Kir3.4 which convey an inwardly rectifying potassium current (IKACh). AZD2927 was used as an investigative compound as a potential treatment for patients with atrial flutter, but efficacy was not shown. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.