AZD3463

Ligand id: 7706

Name: AZD3463

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.09
Molecular weight 448.18
XLogP 3.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
Synonyms
AZD-3463 | CS-1382 | HY-15609 | KB-154896
Database Links
CAS Registry No. 1356962-20-3
GtoPdb PubChem SID 223366039
PubChem CID 56599293
Search Google for chemical match using the InChIKey GCYIGMXOIWJGBU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GCYIGMXOIWJGBU
Search UniChem for chemical match using the InChIKey GCYIGMXOIWJGBU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GCYIGMXOIWJGBU
Comments
AZD3463 was investigated as a treatement for non-small cell lung cancer (NSCLC) patients who have developed resistance to crizotinib. AZD3463 inhibits the tyrosine kinases ALK and IGF1R. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.