AZD5363

Ligand id: 7709

Name: AZD5363

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 7
Topological polar surface area 120.16
Molecular weight 428.17
XLogP 1.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Synonyms
AZD 5363 | AZD-5363 | cc-638
Database Links
CAS Registry No. 1143532-39-1
ChEMBL Ligand CHEMBL2325741
PubChem CID 25227436
RCSB PDB Ligand 0XZ
Search Google for chemical match using the InChIKey JDUBGYFRJFOXQC-KRWDZBQOSA-N
Search Google for chemicals with the same backbone JDUBGYFRJFOXQC
Search UniChem for chemical match using the InChIKey JDUBGYFRJFOXQC-KRWDZBQOSA-N
Search UniChem for chemicals with the same backbone JDUBGYFRJFOXQC
SynPHARM 80200 (in complex with AKT serine/threonine kinase 1)
Comments
AZD5363 was developed as an inhibitor of the AKT serine/threonine protein kinases [1], and was investigated as a potential therapeutic for solid and haematological malignancies. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.