AZ3971

Ligand id: 7804

Name: AZ3971

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.17
Molecular weight 422.19
XLogP 3.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(5S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-pyrimidin-5-ylphenyl)pyrrolo[3,4-b]pyrazin-7-amine
Synonyms
AZ 3971 | AZ-3971
Database Links
PubChem CID 49858172
Search Google for chemical match using the InChIKey BICGYFRWDDPYEI-VWLOTQADSA-N
Search Google for chemicals with the same backbone BICGYFRWDDPYEI
Search UniChem for chemical match using the InChIKey BICGYFRWDDPYEI-VWLOTQADSA-N
Search UniChem for chemicals with the same backbone BICGYFRWDDPYEI
Comments
AZD3971 is an AstraZeneca BACE1 inhibitor. While not published in its own right so far, it has been reported for targeting amyloid beta production in a mouse model of Alzheimer's disease (AD) in combination with the gamma secretase modulator AZ4800 [2].