AZD1080

Ligand id: 7819

Name: AZD1080

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 77.39
Molecular weight 334.14
XLogP 1.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(3E)-3-[5-(morpholin-4-ylmethyl)-1H-pyridin-2-ylidene]-2-oxo-1H-indole-5-carbonitrile
Synonyms
AZD 1080 | AZD-1080 | KB-160506
Database Links
CAS Registry No. 612487-72-6
PubChem CID 16678118
Search Google for chemical match using the InChIKey JULOXTBHCHEFBE-ISLYRVAYSA-N
Search Google for chemicals with the same backbone JULOXTBHCHEFBE
Search UniChem for chemical match using the InChIKey JULOXTBHCHEFBE-ISLYRVAYSA-N
Search UniChem for chemicals with the same backbone JULOXTBHCHEFBE
Comments
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, investigated in Phase I clinical trial for Alzheimer's disease. Development was subsequently discontinued.
This compound was in the AstraZeneca/MRC repurposing list from 2011