AZD1386

Ligand id: 7820

Name: AZD1386

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 78.51
Molecular weight 423.06
XLogP 4.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5'-chloro-7'-methyl-1'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione
Synonyms
AZ12457709 | AZD 1386 | AZD-1386 | KB-270807
Database Links
CAS Registry No. 946080-23-5
PubChem CID 24752296
Search Google for chemical match using the InChIKey DXDVSYALLVVBOV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DXDVSYALLVVBOV
Search UniChem for chemical match using the InChIKey DXDVSYALLVVBOV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DXDVSYALLVVBOV
Comments
AZD1386 is an orally available antagonist of the transient receptor potential channel TRPV1. It acts as a competitive antagonist at the channel's capsaicin binding site .
This compound was in the AstraZeneca/MRC repurposing list from 2011