AZD6605

Ligand id: 7823

Name: AZD6605

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 122.42
Molecular weight 483.11
XLogP 3.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(5S)-5-methyl-5-[[4-[4-(1,1,2,2-tetrafluoroethoxy)phenoxy]piperidin-1-yl]sulfonylmethyl]imidazolidine-2,4-dione
Synonyms
AZ 11920155 | AZ-11920155 | AZ11920155 | AZD 6605 | AZD-6605
Database Links
ChEMBL Ligand CHEMBL2409707
PubChem CID 11641563
Search Google for chemical match using the InChIKey SBVAXUGOISPYPX-QGZVFWFLSA-N
Search Google for chemicals with the same backbone SBVAXUGOISPYPX
Search UniChem for chemical match using the InChIKey SBVAXUGOISPYPX-QGZVFWFLSA-N
Search UniChem for chemicals with the same backbone SBVAXUGOISPYPX
Comments
AZD6605 is a potent, reversible inhibitor of matrix metalloproteinases MMP13 (Collagenase 3), MMP2, MMP9 and MMP12. The discovery of this compound is described in [1], where it is compound 3m.
This compound was in the AstraZeneca/MRC repurposing list from 2011.