ENMD-2076

Ligand id: 7885

Name: ENMD-2076

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 72.97
Molecular weight 375.22
XLogP 5.49
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine
Synonyms
ENMD 2076 | ENMD2076
Database Links
CAS Registry No. 934353-76-1
ChEMBL Ligand CHEMBL482968
PubChem CID 16041424
Search Google for chemical match using the InChIKey BLQYVHBZHAISJM-CMDGGOBGSA-N
Search Google for chemicals with the same backbone BLQYVHBZHAISJM
Search UniChem for chemical match using the InChIKey BLQYVHBZHAISJM-CMDGGOBGSA-N
Search UniChem for chemicals with the same backbone BLQYVHBZHAISJM
Comments
ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor. It inhibits a distinct profile of angiogenic tyrosine kinases in addition to the Aurora A kinase. These angiogenic targets include VEGFR, Flt3 and FGFR3 kinases, which have been shown to play important roles in the pathology of several cancers.