encorafenib

Ligand id: 7908

Name: encorafenib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 148.51
Molecular weight 539.15
XLogP 2.45
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
International Nonproprietary Names
INN number INN
9816 encorafenib
Synonyms
LGX-818 | LGX818
Database Links
CAS Registry No. 1269440-17-6
ChEMBL Ligand CHEMBL3301612
PubChem CID 50922675
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Wikipedia LGX818
Comments
Encorafenib (LGX-818) is an orally available BRAF kinase inhibitor with potential antineoplastic activity.