binimetinib

Ligand id: 7921

Name: binimetinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 88.41
Molecular weight 440.03
XLogP 2.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-[(4-bromo-2-fluorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
International Nonproprietary Names
INN number INN
9764 binimetinib
Synonyms
ARRY 162 | ARRY-162 | ARRY-438162 | MEK-162 | MEK162
Database Links
CAS Registry No. 606143-89-9
ChEMBL Ligand CHEMBL3187723
PubChem CID 10288191
Search Google for chemical match using the InChIKey ACWZRVQXLIRSDF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ACWZRVQXLIRSDF
Search PubMed clinical trials binimetinib
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Search PubMed titles/abstracts binimetinib
Search UniChem for chemical match using the InChIKey ACWZRVQXLIRSDF-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ACWZRVQXLIRSDF
Wikipedia Binimetinib
Comments
Binimetinib is a potent non-ATP competitive inhibitor of MEK1/2 kinase activity [2] (link directly to abstract 794 online here).