apelin receptor early endogenous ligand

Ligand id: 7930

Name: apelin receptor early endogenous ligand

Abbreviated name: ELA

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
APELA apelin receptor early endogenous ligand Human prepro-apelin receptor early endogenous ligand -
Synonyms
ELABELA | Ende | tdl | toddler
Database Links
UniProtKB P0DMC3 (Hs)
Comments
ELA signals via the apelin receptor to mediate endoderm differentiation and embryonic heart morphogenesis, and is present prior to the expression of apelin, making this the earliest ligand recognised by the apelin receptor [1]. More recently (Apr 2017) the activity as an endogenous agonist of the Apelin APJ receptor in the adult cardiovascular system was demonstracted [3].