AT-9283

Ligand id: 7949

Name: AT-9283

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 102.38
Molecular weight 381.19
XLogP -0.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-cyclopropyl-3-[(3Z)-3-[5-(morpholin-4-ylmethyl)benzimidazol-2-ylidene]-1,2-dihydropyrazol-4-yl]urea
Synonyms
AT 9283 | AT9283
Database Links
CAS Registry No. 896466-04-9
PubChem CID 11696609
Search Google for chemical match using the InChIKey VRXXZJLHPWWXIX-ZCXUNETKSA-N
Search Google for chemicals with the same backbone VRXXZJLHPWWXIX
Search UniChem for chemical match using the InChIKey VRXXZJLHPWWXIX-ZCXUNETKSA-N
Search UniChem for chemicals with the same backbone VRXXZJLHPWWXIX
Comments
AT-9283 is a potent Janus kinase 2 and 3 (JAK2/3) and Aurora kinase inhibitor [1]. It is compound 16 in Howard et al. (2009) [1], PubChem CID 11496629 shows the tautomer as drawn in [1]. CHEMBL495727 also represents a tautomeric alternative structure for AT-9283.