BMS-265246

Ligand id: 8051

Name: BMS-265246

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 67.87
Molecular weight 345.13
XLogP 3.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2,6-difluoro-4-methylphenyl)methanone
Synonyms
BMS 265246 | BMS265246
Database Links
CAS Registry No. 582315-72-8
ChEMBL Ligand CHEMBL310840
GtoPdb PubChem SID 249565731
PubChem CID 5329775
Search Google for chemical match using the InChIKey SCFMWQIQBVZOQR-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SCFMWQIQBVZOQR
Search UniChem for chemical match using the InChIKey SCFMWQIQBVZOQR-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone SCFMWQIQBVZOQR
Comments
BMS-265246 is a potent and selective inhibitor of the cyclin-dependent kinases, CDK1 and CDK2 [1], It is 25-fold selective for CDKs 1 and 2 over CDK4.