BIX02188

Ligand id: 8064

Name: BIX02188

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 87.46
Molecular weight 412.19
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxamide
Synonyms
BIX 02188 | BIX-02188
Database Links
CAS Registry No. 1094614-84-2
PubChem CID 66524294
Search Google for chemical match using the InChIKey FSZPIAXLCCQFCM-FCQUAONHSA-N
Search Google for chemicals with the same backbone FSZPIAXLCCQFCM
Search UniChem for chemical match using the InChIKey FSZPIAXLCCQFCM-FCQUAONHSA-N
Search UniChem for chemicals with the same backbone FSZPIAXLCCQFCM
Comments
BIX02188 is an investigational inhibitor of the STE7 family kinase, mitogen-activated protein kinase kinase 5 (MAP2K5) [1]. This compound can be used as a pharmacological tool to help elucidate the role of the MEK5/ERK5 pathway in biological systems. BIX02188 is a closely related, marginally less potent, analogue of BIX02189. Both compounds have a similar selectivity profile.