AC710

Ligand id: 8095

Name: AC710

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 121.62
Molecular weight 562.33
XLogP 6.32
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-5-[(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxy]pyridine-2-carboxamide
Synonyms
AC 710 | AC-710
Database Links
ChEMBL Ligand CHEMBL2206278
GtoPdb PubChem SID 249565775
PubChem CID 54760053
Search Google for chemical match using the InChIKey JVCWPUFNLFSKFS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JVCWPUFNLFSKFS
Search UniChem for chemical match using the InChIKey JVCWPUFNLFSKFS-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone JVCWPUFNLFSKFS
Comments
The design and synthesis of AC710 is described in [1], where it is compound 22b. AC710 is reported as an inhibitor of platelet-derived growth factor receptor (PDGFR) family receptor tyrosine kinases (RTKs). The compound has favourable pharmacodynamics and pharmacokinetics, and is active against mouse xenograft tumours and in a collagen-induced arthritis (CIA) model [1].