EW-7197

Ligand id: 8107

Name: EW-7197

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 83.79
Molecular weight 399.16
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl]aniline
Synonyms
NOV-1301 | TEW-7197
Database Links
CAS Registry No. 1352608-82-2
ChEMBL Ligand CHEMBL3260567
PubChem CID 54766013
Search Google for chemical match using the InChIKey FJCDSQATIJKQKA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FJCDSQATIJKQKA
Search UniChem for chemical match using the InChIKey FJCDSQATIJKQKA-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone FJCDSQATIJKQKA
Comments
The discovery of EW-7197 is reported in [1] where it is compound 12b. EW-7197 acts as in inhibitor of transforming growth factor beta receptor 1B (ALK5) and activin A receptor type IB (ALK4). The compound is potent, selective, and orally bioavailable, and exhibits experimental anti-tumour activity. Proposed INN is vactosertib.