vactosertib

Ligand id: 8107

Name: vactosertib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 83.79
Molecular weight 399.16
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl]aniline
International Nonproprietary Names
INN number INN
10645 vactosertib
Synonyms
EW-7197 | NOV-1301 | TEW-7197
Database Links
CAS Registry No. 1352608-82-2
ChEMBL Ligand CHEMBL3260567
GtoPdb PubChem SID 249565787
PubChem CID 54766013
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Comments
The discovery of vactosertib (EW-7197) is reported in [1] where it is compound 12b. EW-7197 acts as in inhibitor of transforming growth factor beta receptor 1B (ALK5) and activin A receptor type IB (ALK4). The compound is potent, selective, and orally bioavailable, and exhibits experimental anti-tumour activity. Proposed INN is vactosertib.