compound 8h [PMID: 22765894]

Ligand id: 8175

Name: compound 8h [PMID: 22765894]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 73.05
Molecular weight 447.18
XLogP 3.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-[(4-chlorophenyl)-(1H-imidazol-2-yl)methylidene]-5-[(1-ethylpiperidin-4-yl)amino]-1H-indol-2-one
Database Links
ChEMBL Ligand CHEMBL2086760
PubChem CID 67161540
Search Google for chemical match using the InChIKey XHCPCYVQXFHJAU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XHCPCYVQXFHJAU
Search UniChem for chemical match using the InChIKey XHCPCYVQXFHJAU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XHCPCYVQXFHJAU
Comments
Compound 8h is reported to be a potent inhibitor of several receptor tyrosine kinases, including VEGFRs 1-3, PDGFR, and FGFR1, as well the Src family kinases Src and Yes and the serine threonine kinases MAP4K3 and Rsk2 [1].