BLZ945

Ligand id: 8250

Name: BLZ945

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 124.61
Molecular weight 398.14
XLogP 2.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
Synonyms
BLZ 945 | BLZ-945
Database Links
CAS Registry No. 953769-46-5
PubChem CID 46184986
Search Google for chemical match using the InChIKey ADZBMFGQQWPHMJ-RHSMWYFYSA-N
Search Google for chemicals with the same backbone ADZBMFGQQWPHMJ
Search UniChem for chemical match using the InChIKey ADZBMFGQQWPHMJ-RHSMWYFYSA-N
Search UniChem for chemicals with the same backbone ADZBMFGQQWPHMJ
Comments
BLZ945 is reported as an orally active, potent and selective inhibitor of colony stimulating factor 1 receptor (CSF1R) [2]. The compound was designed to deplete pro-tumorigenic tumour-associated macrophages (TAMs) in the tumour microenvironment [2], and has also been reported to inhibit osteoclast CSF1R activity which reduces skeletal related events in metastatic disease [1].