CPHPC

Ligand id: 8256

Name: CPHPC

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 115.22
Molecular weight 340.16
XLogP -0.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2R)-1-[6-[(2R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid
Synonyms
compound 52 [PMID 14998318] [5] | GSK2315698 | Ro 63-8695 [5]
Database Links
CAS Registry No. 224624-80-0
ChEMBL Ligand CHEMBL25263
PubChem CID 125516
RCSB PDB Ligand GHE
Search Google for chemical match using the InChIKey HZLAWYIBLZNRFZ-VXGBXAGGSA-N
Search Google for chemicals with the same backbone HZLAWYIBLZNRFZ
Search UniChem for chemical match using the InChIKey HZLAWYIBLZNRFZ-VXGBXAGGSA-N
Search UniChem for chemicals with the same backbone HZLAWYIBLZNRFZ
SynPHARM 81894 (in complex with amyloid P component, serum)
Wikipedia CPHPC
Comments
CPHPC is reported as a chemical which depletes the glycoprotein serum amyloid P component (SAP) in mice [1] and humans [2]. Intellectual property for the use of CPHPC has been licensed to GlaxoSmithKline who have coded the compound GSK2315698. Structurally, CPHPC is a simplified form of a captopril dimer [5].