avosentan

Ligand id: 8260

Name: avosentan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 133.8
Molecular weight 479.13
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[6-methoxy-5-(2-methoxyphenoxy)-2-pyridin-4-ylpyrimidin-4-yl]-5-methylpyridine-2-sulfonamide
International Nonproprietary Names
INN number INN
8530 avosentan
Synonyms
Ro 67-0565 | SPP-301
Database Links
CAS Registry No. 290815-26-8 (source: Scifinder)
GtoPdb PubChem SID 249565940
PubChem CID 9912992
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Comments
Avosentan is an endothelin A antagonist indicated for diabetic nephropathy. Speedel licensed SPP301 from Hoffmann-La Roche in 2000.