(-)-englerin A

Ligand id: 8372

Name: (-)-englerin A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 82.06
Molecular weight 442.24
XLogP 6.65
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Database Links
PubChem CID 46242512
Search Google for chemical match using the InChIKey GACOFEKSDCOVMV-RRYXBOBMSA-N
Search Google for chemicals with the same backbone GACOFEKSDCOVMV
Search UniChem for chemical match using the InChIKey GACOFEKSDCOVMV-RRYXBOBMSA-N
Search UniChem for chemicals with the same backbone GACOFEKSDCOVMV
Comments
(-)-englerin A is a plant extract from the bark of Phyllanthus engleri [4]. (-)-englerin A is a potent and selective agonist of TRPC4 and TRPC5 calcium channels [1] with cytotoxic activity selective for several renal cancer cell lines [4]. The (+) enantiomer is inactive against the same cells [3]. The compound has been chemically synthesised [2-3,5].