daprodustat

Ligand id: 8455

Name: daprodustat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 124.09
Molecular weight 393.19
XLogP 1.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
Synonyms
GSK-1278863 | GSK1278863
Database Links
CAS Registry No. 960539-70-2
PubChem CID 91617630
Search Google for chemical match using the InChIKey RUEYEZADQJCKGV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone RUEYEZADQJCKGV
Search UniChem for chemical match using the InChIKey RUEYEZADQJCKGV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone RUEYEZADQJCKGV
Comments
Daprodustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD). It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients