niclosamide

Ligand id: 8494

Name: niclosamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 92.47
Molecular weight 325.99
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Synonyms
VU0243604
Database Links
GtoPdb PubChem SID 252166702
PubChem CID 4477
Search Google for chemical match using the InChIKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone RJMUSRYZPJIFPJ
Search UniChem for chemical match using the InChIKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone RJMUSRYZPJIFPJ
Comments
STAT3 inhibitor; inhibits mTORC1 signaling; positive allosteric modulator (PAM) of the neuropeptide Y4 receptor [2].

Evidence from repurposing studies suggests some activity against methicillin-resistant Staphylococcus aureus (MRSA), and Zika virus (in vitro) [3].