compound 5b [PMID: 16686537]

Ligand id: 8616

Name: compound 5b [PMID: 16686537]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 18
Topological polar surface area 113.6
Molecular weight 475.3
XLogP 6.81
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
phenylmethyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Synonyms
MG-132 | MG132 | Z-Leu-leu-leu-al | Z-LLL-CHO
Database Links
CAS Registry No. 133407-82-6 (source: PubChem)
ChEMBL Ligand CHEMBL64925
PubChem CID 462382
RCSB PDB Ligand LDZ
Search Google for chemical match using the InChIKey TZYWCYJVHRLUCT-VABKMULXSA-N
Search Google for chemicals with the same backbone TZYWCYJVHRLUCT
Search UniChem for chemical match using the InChIKey TZYWCYJVHRLUCT-VABKMULXSA-N
Search UniChem for chemicals with the same backbone TZYWCYJVHRLUCT
Comments
Compound 5b is reported to inhibit the enzymatic activity of proteasome macropain [1].