enoxacin

Ligand id: 8882

Name: enoxacin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 85.77
Molecular weight 320.13
XLogP 0.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1991))
Withdrawn drug? Yes
IUPAC Name
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid
International Nonproprietary Names
INN number INN
5351 enoxacin
Synonyms
Flumark® | Penetrex®
Database Links
CAS Registry No. 74011-58-8 (source: PubChem)
ChEBI CHEBI:157175
ChEMBL Ligand CHEMBL826
DrugBank Ligand DB00467
PubChem CID 3229
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Comments
enoxacin has been reorted as an inhibitor of the interaction between the B2 subunit of vacuolar H+-ATPase (ATP6V1B2) and microfilaments [2], an interaction required for translocation of the ATPase to the plasma membrane. This process effects activation of osteoclasts and regulates bone resorption, making this interaction a novel target for pharmaceutical intervention to reduce the pathologies associated with bone-loss condtions [3].