altiratinib

Ligand id: 9174

Name: altiratinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 109.42
Molecular weight 510.15
XLogP 5.13
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-N'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
International Nonproprietary Names
INN number INN
10100 altiratinib
Synonyms
DCC-270 | DCC-2701 | DP-5164
Database Links
CAS Registry No. 1345847-93-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL3545365
GtoPdb PubChem SID 315661257
PubChem CID 54576299
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Comments
Altiratinib is an oral, selective and potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases, being investigated for its potential anticancer activity. This specific compound is claimed in patent WO2016061231 [1], and prior patent submissions.