clofazimine

Ligand id: 9184

Name: clofazimine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 27.63
Molecular weight 472.12
XLogP 7.97
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1986))
IUPAC Name
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
International Nonproprietary Names
INN number INN
2248 clofazimine
Synonyms
Lamprene®
Database Links
ChEMBL Ligand CHEMBL1292
GtoPdb PubChem SID 315661264
PubChem CID 2794
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Comments
Clofazimine is a phenazine dye with anti-mycobacterial action (possibly via DNA binding) but is no longer perscribed in the US. It also has anti-inflammatory activities. State-dependent block of Kv1.3 channels by clofazimine offers therapeutic potential for selective immunosuppression in the context of autoimmune diseases in which Kv1.3-expressing T cells play a significant role [2].