CC-885

Ligand id: 9224

Name: CC-885

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 107.61
Molecular weight 440.13
XLogP 1.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-(3-chloro-4-methylphenyl)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea
Database Links
PubChem CID 24788636
Search Google for chemical match using the InChIKey DOEVCIHTTTYVCC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DOEVCIHTTTYVCC
Search UniChem for chemical match using the InChIKey DOEVCIHTTTYVCC-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DOEVCIHTTTYVCC
Comments
Structural studies have shown that immunomodulatory drugs bind in a shallow hydrophobic pocket on the surface of cereblon, mediated by a glutarimide ring. The broad activity profile of CC-885 is highly differentiated from that of thalidomide, lenalidomide and pomalidomide. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour cells exhibit high sensitivity to CC-885, indicating the clinical potential of this mechanism [1].