AZ191

Ligand id: 9268

Name: AZ191

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 71.34
Molecular weight 429.23
XLogP 2.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
Synonyms
AZ-191 | Compound 19 [PMID25738750]
Database Links
CAS Registry No. 1594092-37-1 (source: PubChem)
ChEMBL Ligand CHEMBL3421968
GtoPdb PubChem SID 315661343
PubChem CID 72716071
Search Google for chemical match using the InChIKey ZYVXTMKTGDARKR-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZYVXTMKTGDARKR
Search UniChem for chemical match using the InChIKey ZYVXTMKTGDARKR-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZYVXTMKTGDARKR
Comments
AZ191 is a potent and selective small molecule inhibitor of DYRK1B from AstraZeneca [2]. Results of a 2014 study [1] using AZ191 indicate DYRK1B is a novel Thr(286)-CCND1(cyclinD1) kinase that acts independently of GSK3β to regulate the mammalian G1-S-phase transition. This compound is included in the Probe Portal as SGC AZ191.