AZD7594

Ligand id: 9325

Name: AZD7594

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 112.94
Molecular weight 606.23
XLogP 4.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-[5-[(1R,2S)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-(oxolan-3-yl)benzamide
Synonyms
AZ13189620
Database Links
PubChem CID 44516034
Search Google for chemical match using the InChIKey ZZWJKLGCDHYVMB-QMQODZDESA-N
Search Google for chemicals with the same backbone ZZWJKLGCDHYVMB
Search UniChem for chemical match using the InChIKey ZZWJKLGCDHYVMB-QMQODZDESA-N
Search UniChem for chemicals with the same backbone ZZWJKLGCDHYVMB
Comments
AZD7594 is a novel non-steroidal modulator of inflammation. Functionally it is a selective glucocorticoid receptor modulator (SGRM) delivered by inhalation, being developed for asthma and COPD. Stereoisomers with 3S and 3R configuration at the bond with the tetrahydrofuran group are claimed in patent US8916600 (Examples 5 and 6 respectively) [1], although we show no chiral-specification at this bond. We will be able to confirm chirality when the compound is declared in a peer reviewed publication.