compound 5 [PMID: 17618114]

Ligand id: 9348

Name: compound 5 [PMID: 17618114]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 87.08
Molecular weight 439.14
XLogP 4.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
Tie2 kinase inhibitor
Database Links
ChEMBL Ligand CHEMBL237352
PubChem CID 23625762
Search Google for chemical match using the InChIKey SINQIEAULQKUPD-UHFFFAOYSA-N
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Comments
Compound 5 [PMID: 17618114] is an inhibitor of TEK receptor tyrosine kinase (a.k.a. TIE2) [1]. Compound 5 was SAR optimised from lead SB203580. Small molecule Tie2 inhibitors are being developed for potential use as anti-angiogenic cancer therapeutics.