AZD7545

Ligand id: 9362

Name: AZD7545

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 112.16
Molecular weight 478.06
XLogP 2.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N,N-dimethylbenzamide
Synonyms
AZD-7545
Database Links
CAS Registry No. 252017-04-2 (source: PubChem)
PubChem CID 16741245
RCSB PDB Ligand AZX
Search Google for chemical match using the InChIKey DTDZLJHKVNTQGZ-GOSISDBHSA-N
Search Google for chemicals with the same backbone DTDZLJHKVNTQGZ
Search UniChem for chemical match using the InChIKey DTDZLJHKVNTQGZ-GOSISDBHSA-N
Search UniChem for chemicals with the same backbone DTDZLJHKVNTQGZ
Comments
AZD7545 is a non-ATP competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), designed for its glucose-lowering (anti-diabetes) activity [1].