BMS-536924

Ligand id: 9386

Name: BMS-536924

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 98.22
Molecular weight 479.17
XLogP 3.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
BMS 536924 | BMS536924 | compound 1 [PMID: 18763755] | compound 3 [PMID: 16134929]
Database Links
CAS Registry No. 468740-43-4 (source: PubChem)
PubChem CID 11353973
Search Google for chemical match using the InChIKey UGQMURPIMYALPH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone UGQMURPIMYALPH
Search UniChem for chemical match using the InChIKey UGQMURPIMYALPH-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone UGQMURPIMYALPH
Comments
BMS-536924 is an experimental inhbitor of insulin-like growth factor-1 receptor kinase which inhibits insulin-like growth factor-I receptor dependent tumour growth in vivo [2]. However, its utility is hampered by its potential to cause drug-drug interactions via inhibition of CYP3A4, and ability to increase CYP3A4 protein expression [1].